Development and validation of a prediction model for moderately severe and severe acute pancreatitis in pregnancy

Table 1 Demographics and clinical characteristics of acute pancreatitis patients in pregnancy

Parameters	MAIP (n = 136)	MSIP (n = 54)	P value
Age	27.61 ± 5.25	29.46 ± 5.57	0.032
Etiology			0.514
Hypertriglyceridemia	50 (36.8)	24 (44.4)
Gallstone	45 (33.1)	19 (35.2)
Other	41 (30.1)	11 (20.4)
Comorbidity
Hypertension	0 (0.0)	2 (3.7)	0.080
Diabetes	8 (5.9)	13 (24.1)	0.001
Fatty liver disease	32 (23.5)	16 (29.6)	0.492
Smoking	3 (2.2)	2 (3.7)	0.937
Drinking	4 (2.9)	1 (1.9)	1.000
Trimester of pregnancy on admission
Early (1–12 wk)	9 (6.6)	3(5.6)
Mid (12–24 wk)	31 (22.8)	10(18.5)
Late (24–40 wk)	96 (70.6)	41(75.9)
Gestational weeks on admission	28.04 ± 7.72	28.80 ± 6.64	0.520
Onset to admission (days)	1.59 ± 1.37	1.88 ± 1.65	0.220
Blood infection	0 (0.0)	8 (14.8)	< 0.001
LOS	7.25 ± 4.27	11.88 ± 7.42	< 0.001
Fetal death	3 (2.2)	13(24.1)	< 0.001
Maternal hospital mortality	0 (0.0)	1(2.9)	0.284
Hematocrit	0.33 ± 0.05	0.32 ± 0.06	0.155
Platelet	164.42 ± 55.01	147.55 ± 65.17	0.072
WBC	12.59 ± 4.71	14.15 ± 4.15	0.035
Neutrophils	10.86 ± 4.40	12.49 ± 3.97	0.019
Lymphocytes	1.01 ± 0.40	0.88 ± 0.47	0.068
Monocytes	0.55 ± 0.23	0.48 ± 0.27	0.064
Alanine aminotransferase	50.94 ± 78.74	19.57 ± 37.40	0.006
Albumin	34.22 ± 3.70	29.36 ± 5.17	< 0.001
Creatinine	42.57 ± 9.30	75.87 ± 100.15	< 0.001
Aspartate aminotransferase	51.17 ± 67.61	35.07 ± 50.13	0.115
Alkaline phosphatase	113.56 ± 52.19	95.38 ± 36.87	0.020
Creatine kinase	36.20 ± 25.87	126.36 ± 213.49	< 0.001
LDH	185.32 ± 66.39	346.93 ± 208.95	< 0.001
Triglyceride	5.87 ± 6.72	12.57 ± 7.34	< 0.001
Cholesterol	7.34 ± 5.63	12.80 ± 6.64	< 0.001
High density lipoprotein	1.40 ± 0.48	1.16 ± 0.39	0.001
Low density lipoprotein	2.24 ± 1.23	1.94 ± 1.59	0.158
Sodium	135.62 ± 3.82	133.57 ± 5.43	0.004
Potassium	3.76 ± 0.34	3.83 ± 0.46	0.294
Chlorine	102.17 ± 4.46	102.44 ± 6.40	0.735

MAIP: Mild acute pancreatitis in pregnancy; MSIP: Moderately severe and severe acute pancreatitis in pregnancy; LOS: Length of hospital stay; WBC: White blood cell; LDH: Lactate dehydrogenase.