Hepatocellular adenoma in the paediatric population: Molecular classification and clinical associations

Figure 1 Hepatocellular adenoma in a child with glycogen storage disease type 1A. A: a well-differentiated hepatocellular lesion with scattered macrovesicular steatosis and unpaired arterioles (arrow), while complete portal tracts are not identified (hematoxylin and eosin, 4 ×); B: the lesional hepatocytes are negative for liver fatty acid binding protein immunohistochemical stain (4 ×); inset shows normal hepatocytes with immunohistochemical expression of liver fatty acid binding protein (10 ×); C: Moreover, the lesion demonstrates absence of nuclear beta catenin immunostaining (membranous staining is identified; 10 ×). The overall pathologic findings are in keeping with an hepatocyte nuclear factor 1 homeobox alpha-inactivated hepatocellular adenoma.