Role of interleukin-22 in inflammatory bowel disease

doi:10.3748/wjg.v20.i48.18177

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Dec 28, 2014 (publication date) through Dec 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2014; 20(48): 18177-18188
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18177

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Figure 1 Interleukin-22 signaling pathway. IL-22 binds to a heterodimeric receptor composed of IL-10R2 and IL-22R1, activating JAK1 and TYK2, which self-phosphorylate, resulting in binding and phosphorylation of STAT3. Then, STAT3 translocates to the nucleus and induces target genes. IL: Interleukin; JAK: Janus kinase; TYK: Tyrosine protein kinase; STAT: Signal transducer and activator of transcription.

Citation: Li LJ, Gong C, Zhao MH, Feng BS. Role of interleukin-22 in inflammatory bowel disease. World J Gastroenterol 2014; 20(48): 18177-18188
URL: https://www.wjgnet.com/1007-9327/full/v20/i48/18177.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i48.18177