Li LJ, Gong C, Zhao MH, Feng BS. Role of interleukin-22 in inflammatory bowel disease. World J Gastroenterol 2014; 20(48): 18177-18188 [PMID: 25561785 DOI: 10.3748/wjg.v20.i48.18177]
Corresponding Author of This Article
Bai-Sui Feng, MD, PhD, Professor, Department of Gastroenterology, the Fifth Affiliated Hospital of Zhengzhou University, 3 Kangfu Front Street, Erqi District, Zhengzhou 450000, Henan Province, China. fbs163@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Lin-Jing Li, Chen Gong, Mei-Hua Zhao, Bai-Sui Feng, Department of Gastroenterology, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Author contributions: Li LJ, Gong C and Zhao MH collected the materials and wrote the manuscript; and Feng BS reviewed the manuscript and supervised the research work.
Supported by National Natural Science Foundation of China, No. 81070288 and No. 81270452; Medical Science and Technology Foundation of Henan Province, No. 201001004; and Science and Technology Leader Overseas Training Foundation of Henan Province, No. 201201013
Correspondence to: Bai-Sui Feng, MD, PhD, Professor, Department of Gastroenterology, the Fifth Affiliated Hospital of Zhengzhou University, 3 Kangfu Front Street, Erqi District, Zhengzhou 450000, Henan Province, China. fbs163@163.com
Telephone: +86-371-66916927 Fax: +86-371-66902232
Received: May 5, 2014 Revised: June 21, 2014 Accepted: September 5, 2014 Published online: December 28, 2014 Processing time: 245 Days and 16 Hours
Core Tip
Core tip: Interleukin (IL)-22 is expressed by adaptive immune system cells and innate lymphocytes. Several cytokines and many transcriptional factors and T regulatory cells can regulate IL-22 expression. Through activation of signal transducer and activator of transcription 3 signaling cascades, IL-22 induces antimicrobial, proliferative and antiapoptotic pathways, which can help fix damaged tissue and promote tissue repair mechanisms. IL-22 is also associated with inflammatory bowel disease (IBD) susceptibility genes that regulate inflammatory responses in tissues. All of these processes play crucial roles in IBD pathogenesis and collectively provide an important rationale for the development of novel therapeutic measures for this disease.
