Published online Sep 15, 1996. doi: 10.3748/wjg.v2.iSuppl1.52
Revised: April 22, 1996
Accepted: May 13, 1996
Published online: September 15, 1996
AIM: The effect of different doses of Rhizoma Atractylodis Macrocephalae (RAM) on the spontaneous contraction of isolated guinea pig ileum was examined.
METHODS: RAM 0.1 μ slightly inhibited the spontaneous contraction of isolated guinea pig ileum; RAM 0.2 μ or higher concentrations significantly enhanced the spontaneous contraction of isolated guinea pig ileum in dose dependent manner. The distance traveled by charcoal meal through the small intestine in mice measured in terms of propulsive motility.
RESULTS: (1) RAM 0.1 mg/10 g weight markedly increased the propulsive distance of charcoal meal in mice, the effects were abolished by atropin (0.1 mg/10 g weight IP); (2) Regitine (0.03 mg/10 g weight IP) partly blocked the increased gastrointestinal propulsive motility by RAM; (3) No effects were found on the increased gastrointestinal propulsive motility after injection of propranolol (0.07 mg/10 g with IP).
CONCLUSION: The results indicate that RAM has an exciting effect on the propulsive motility of gastrointestinal tract, which may be mediated via M receptor and α receptor.
- Citation: Ma XS, Xin YS. Effect and mechanism of Rhizoma Atractylodis Macrocephalae on gastrointestinal motility in animals. World J Gastroenterol 1996; 2(Suppl1): 52-52
- URL: https://www.wjgnet.com/1007-9327/full/v2/iSuppl1/52.htm
- DOI: https://dx.doi.org/10.3748/wjg.v2.iSuppl1.52
Original title:
E- Editor: Liu WX