Prognostic significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in human gastric carcinoma

Figure 1 Immunohistochemical staining of COX-2 protein in gastric carcinoma. Immunoreactivity for COX-2 protein was present in the cytoplasm of tumor cells, smooth muscle cells (A, × 200), and surrounding glands (B, × 100).

Figure 2 Positive immunostaining for COX-2 was observed in some CAG specimens (× 100).

Figure 3 Immunohistochemical staining for VEGF in gastric carcinoma. VEGF was mainly localized on the membrane of the carcinoma cells or in the cytoplasm (× 200).

Figure 4 Kaplan-Meier survival curves of patients with gastric carcinoma with regard to COX-2 expression (positive and negative), χ² = 7. 56, P < 0.01.

Figure 5 Kaplan-Meier survival curves of patients with gastric carcinoma with regard to VEGF expression (positive and negative), χ² = 16. 51, P < 0.01.