Chronic ulcerative colitis model in rats

Figure 1 Rats were killed 3wk after intracolon ic administration of 25 mg/kg-150 mg/kg of TNBS. Colonic damage, colon weight and tissue MPO activity were assayed. Data of TNBS-treated rats were compared with control (30% ethanol) group by Student’s t test, ^aP < 0.05, ^bP < 0.01.

Figure 2 Histological findings in ulcerative colitis induced by different doses of TNBS ethanol. a: TNBS 25 mg/kg, the mucosa is normal. b: TNBS 50 g/kg, small mucosal ulc ers and cryptoabscess formation. c-d: TNBS 100 mg/kg, mucosal ulcers, in flammatory exudate, proliferous granulomas and cells infiltration. e-f: TNBS 150 g/kg, gross ulcers and proliferous granulomas, necrosis of epithelium at mu cosal sueface and inflammatory cell infiltration (He, × 100)

Figure 3 The effects of intracolonic administration of 100 mg/kg of TNBS on MPO activity 1 wk-8 wk after administration. Each bar represents the ^-x ± s of 5 animals. All data for TNBS-tr eated rats were compared with 0 wk (control group). ^aP < 0.05, ^bP < 0.01.