Important role of lymphovascular and perineural invasion in prognosis of colorectal cancer patients with N1c disease

Figure 1 Groups divided according to lymphovascular invasion or perineural invasion had different prognosis. A: Lymphovascular invasion (LVI) predicting disease-free survival (DFS) (P = 0.00011); B: LVI predicting overall survival (OS) (P < 0.0001); C: LVI predicting cancer-specific survival (CSS) (P < 0.0001); D: Perineural invasion (PNI) predicting DFS (P = 0.00011); E: PNI predicting OS (P < 0.0001); F: PNI predicting CSS (P = 0.00028). LVI: Lymphovascular invasion; PNI: Perineural invasion.

Figure 2 Three groups divided according to presence of lymphovascular invasion and perineural invasion had different prognosis. A: Predicting disease-free survival (P < 0.0001); B: Predicting overall survival (P < 0.0001); C: Predicting cancer-specific survival (P < 0.0001). LVI: Lymphovascular invasion; PNI: Perineural invasion.

Figure 3 Receiver operating characteristic curve on the predictive prognosis. A: Lymphovascular invasion (LVI) predicting disease-free survival (DFS); B: Perineural invasion (PNI) predicting DFS; C: LVI predicting overall survival (OS); D: PNI predicting OS; E: LVI predicting cancer-specific survival (CSS); F: PNI predicting CSS; G: Three groups predicting DFS; H: Three groups predicting OS; I: Three groups predicting CSS. LVI: Lymphovascular invasion; DFS: Disease-free survival; OS: Overall survival; CSS: Cancer-specific survival; AUC: Area under the receiver operating characteristic; PNI: Perineural invasion.