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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2025; 31(5): 102210
Published online Feb 7, 2025. doi: 10.3748/wjg.v31.i5.102210
Published online Feb 7, 2025. doi: 10.3748/wjg.v31.i5.102210
Important role of lymphovascular and perineural invasion in prognosis of colorectal cancer patients with N1c disease
Zhi-Gang Sun, Shao-Xuan Chen, Bai-Long Sun, Da-Kui Zhang, Zi-Han Han, Zhi-Yong Hou, Li Yao, Jian-Zheng Jie, Department of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China
Hong-Liang Sun, Yu-Wan Hu, Tong-Yin Zhang, Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China
Huang Chen, Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China
Yu-Wan Hu, Tong-Yin Zhang, Wen-Xiao Wu, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China
Wen-Xiao Wu, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China
Author contributions: Sun ZG, Chen SX, Jie JZ designed the research; Sun BL, Zhang DK, Han ZH, Wu WX, Hou ZY, Yao L assisted in data collection; Sun HL, Hu YW, Zhang TY verified imaging data; Chen H verified pathological data; Sun ZG, Chen SX, Jie JZ performed the research; All authors have read and approve the final manuscript.
Supported by the National High Level Hospital Clinical Research Funding, No. 2023-NHLHCRF-BQ-32 and No. 2023-NHLHCRF-YYPPLC-ZR-13; and the Elite Medical Professionals Project of China-Japan Friendship Hospital, No. ZRJY2024-GG01.
Institutional review board statement: This study was a retrospective research, using anonymous cases and did not involve ethical issues. According to relevant policies of the China-Japan Friendship Hospital Review Board, ethical review was exempted.
Informed consent statement: The requirement to obtain the informed consent was waived.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Zheng Jie, Chief Physician, MD, Department of General Surgery, China-Japan Friendship Hospital, No. 2 Yinghuayuan East Street, Chaoyang District, Beijing 100029, China. jianzhengjie@sohu.com
Received: October 23, 2024
Revised: December 4, 2024
Accepted: December 16, 2024
Published online: February 7, 2025
Processing time: 68 Days and 0.3 Hours
Revised: December 4, 2024
Accepted: December 16, 2024
Published online: February 7, 2025
Processing time: 68 Days and 0.3 Hours
Core Tip
Core Tip: This study evaluated lymphovascular invasion (LVI) and perineural invasion (PNI) as prognostic indicators in N1c colorectal cancer. Among 107 N1c patients, 21.5% were LVI-positive and 44.9% were PNI-positive. Five-year disease-free survival (DFS) rates were higher for LVI-negative (74.0%) and PNI-negative (82.5%) patients than LVI-positive (35.6%) and PNI-positive (45.1%) patients. On multivariate analysis, both LVI and PNI were independent prognostic factors. Receiver operating characteristic curve analysis showed good predictive ability for DFS, overall survival and cancer-specific survival. Patients with LVI or PNI should be closely monitored during treatment.