Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study

Figure 1 Schematic flow diagram of study design. RH: Reflux hypersensitivity.

Figure 2 Proportion of extraesophageal symptoms and esophageal related symptoms in reflux hypersensitivity patients.

Figure 3 Comparison of reflux parameters for a continuous 24-hour period. A: pH of the reflux; B: Physical state of the reflux; C: Position during acidic reflux. ^aP < 0.05; ^bP < 0.0001. AET: Acid exposure time.

Figure 4 Comparison of parameters between patients with extraesophageal symptoms and without extraesophageal symptoms. A: Age; B: Nonacidic reflux time; C: Intraabdominal length of the lower esophageal sphincter. ^aP < 0.05. EES: Extraesophageal symptoms; LES: Lower esophageal sphincter.

Figure 5 Comparison of parameters based on gender. A: Body mass index; B: Demeester score; C: Peristaltic contraction break length; D: Distal contractile integral; E: Times of different reflux events. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. BMI: Body mass index; PCBL: Peristaltic contraction break length; DCI: Distal contractile integral; AR: Acidic reflux; WAR: Weakly acidic reflux; NAR: Nonacidic reflux.