Wu YP, Zhou JX, Wu HB, Wu DP, Qin LZ, Qin B, Xu XY, Yehya SAA, Cheng Y. Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study. World J Gastroenterol 2025; 31(17): 105281 [DOI: 10.3748/wjg.v31.i17.105281]
Corresponding Author of This Article
Yan Cheng, PhD, Chief Physician, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 Xiwu Street, Xi’an 710000, Shaanxi Province, China. 15609264849@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. May 7, 2025; 31(17): 105281 Published online May 7, 2025. doi: 10.3748/wjg.v31.i17.105281
Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study
Yan-Ping Wu, Jia-Xuan Zhou, Hong-Bo Wu, Di-Ping Wu, Ling-Zhi Qin, Bin Qin, Xiao-Yu Xu, Saleh Abdulaziz Abdulgani Yehya, Yan Cheng
Yan-Ping Wu, Jia-Xuan Zhou, Hong-Bo Wu, Ling-Zhi Qin, Bin Qin, Xiao-Yu Xu, Saleh Abdulaziz Abdulgani Yehya, Yan Cheng, Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710000, Shaanxi Province, China
Di-Ping Wu, Department of Cyberspace Security, Beijing Electronic Science and Technology Institute, Beijing 100000, China
Author contributions: Cheng Y contributed to the conceptualization and supervision of the manuscript; Wu YP was involved in the validation of this study; Wu YP, Zhou JX, and Wu HB participated in the data curation; Wu YP and Zhou JX contributed to the investigation; Wu YP and Wu DP took part in the visualization; Wu YP and Qin LZ contributed to the writing - original draft preparation; Qin B contributed to the methodology of the manuscript; Xu XY was responsible to the software; Yehya SAA contributed to the writing - reviewing and editing.
Supported by the Foundation of the Second Affiliated Hospital of Xi’an Jiaotong University, No. YJ(ZD)202301.
Institutional review board statement: The Institutional Review Board of the Second Affiliated Hospital of Xi’an Jiaotong University approved the study (Approval number: 2023262).
Informed consent statement: Informed consent was obtained from all participants in this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data supporting the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Cheng, PhD, Chief Physician, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 Xiwu Street, Xi’an 710000, Shaanxi Province, China. 15609264849@163.com
Received: January 17, 2025 Revised: March 7, 2025 Accepted: April 17, 2025 Published online: May 7, 2025 Processing time: 102 Days and 17.7 Hours
Core Tip
Core Tip: Reflux hypersensitivity (RH) significantly contributes to heartburn. However, its underlying mechanisms are not fully comprehended. This retrospective study examined data from 92 patients diagnosed with RH and 104 healthy controls to explore clinical characteristics and potential risk factors. The results demonstrate that weakly acidic reflux and nonacidic reflux are integral to the pathophysiology of RH. Furthermore, extraesophageal symptoms were correlated with a younger age and elevated levels of nonacidic reflux. Independent risk factors identified for RH encompass age, the existence of a hiatal hernia, and anxiety. These findings highlight the intricate relationship between reflux subtypes and psychological factors in RH, offering new perspectives for individualized diagnostic and therapeutic strategies.
