Role of transient elastography in the diagnosis and prognosis of Fontan-associated liver disease

Figure 1 Area under the curve of liver stiffness measurement by transient elastography for the diagnosis of Fontan-associated liver disease. The area under the curve is 0.905. AUC: Area under curve; CI: Confidence interval.

Figure 2 Fontan-associated liver disease algorithm based on the liver stiffness measurement by transient elastography and elapsed time since Fontan surgery. The algorithm rules-out Fontan-associated liver disease (FALD) when the liver stiffness measurement by transient elastography (FibroScan^®) is < 15 kPa, and rules-in FALD when it is ≥ 25 kPa. For patients in the “grey area” of 15-25 kPa, elapsed time since Fontan surgery is used. When the time elapsed is ≤ 10 years, FALD is ruled-out, and when it is > 10 years, it is ruled-in. FALD: Fontan-associated liver disease; PPV: Positive predictive value; NPV: Negative predictive value.