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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2025; 31(11): 103178
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.103178
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.103178
Role of transient elastography in the diagnosis and prognosis of Fontan-associated liver disease
Marta Cuadros, Marta Abadía, Pilar Castillo, María Dolores Martín-Arranz, Nerea Gonzalo, Miriam Romero, Araceli García-Sánchez, Javier García-Samaniego, Antonio Olveira, Consuelo Froilán, Department of Gastroenterology and Hepatology, Hospital Universitario La Paz, Madrid 28046, Spain
José Ruiz-Cantador, Inés Ponz, Pablo Merás, Carlos Merino, Adriana Rodríguez-Chaverri, Enrique Balbacid, Department of Cardiology, Hospital Universitario La Paz, Madrid 28046, Spain
Óscar González-Fernández, Adult Congenital and Pediatric Heart Unit, Freeman Hospital, Newcastle Hospitals NHS Foundation Trust, Newcastle NE7 7DN, Newcastle upon Tyne, United Kingdom
Author contributions: Cuadros M, Froilán C, Abadía M, Castillo P, Gonzalo N, Ponz I, Balbacid E designed the research study; Cuadros M, Froilán C, Abadía M, Castillo P, Martín-Arranz MD, Gonzalo N, Romero M, García-Sánchez A, Garcia-Samaniego J, Olveira A, Ruiz-Cantador J, Ponz I, Merás P, Merino C, Rodríguez-Chaverri A, Balbacid E, González-Fernández Ó performed the research; Cuadros M, Froilán C, Abadía M, Castillo P collaborated in the writing and editing of the manuscript; All authors have read and approve the final manuscript.
Institutional review board statement: This study was approved by the Research Ethics Board at Hospital Universitario La Paz (No. PI-5510).
Informed consent statement: This is a retrospective observational study in which data were collected from medical reports, without subject participation, and without any intervention. Consent was not obtained, but the presented data are anonymized and the risk of identification is low.
Conflict-of-interest statement: All authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: The technical appendix, statistical code, and dataset available from the corresponding author at cuadrosmartinez@gmail.com. Participant consent was not obtained, but the presented data are anonymized and the risk of identification is low.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marta Cuadros, MD, Department of Gastroenterology and Hepatology, Hospital Universitario La Paz, Paseo de la Castellana, 261, Madrid 28046, Spain.
Received: November 11, 2024
Revised: January 12, 2025
Accepted: February 25, 2025
Published online: March 21, 2025
Processing time: 122 Days and 15.6 Hours
Revised: January 12, 2025
Accepted: February 25, 2025
Published online: March 21, 2025
Processing time: 122 Days and 15.6 Hours
Core Tip
Core Tip: There was a significant association between liver stiffness measurement (LSM) by transient elastography (TE) and Fontan-associated liver disease (FALD). We obtained areas under the curve (AUC) of 0.905 for FALD and 0.764 for advanced FALD. The optimal cut-off values were 20 kPa for FALD and 25 kPa for advanced FALD. An algorithm for FALD was proposed based on LSM by TE and elapsed time since Fontan surgery with an AUC of 0.877. We also demonstrated an association between LSM by TE and clinically relevant events (heart or heart-liver transplantation indication, hepatocellular carcinoma, and all-cause mortality).