Roles of autophagy and long non-coding RNAs in gastric cancer

Figure 1 Regulatory loop between autophagy and long non-coding RNAs in gastric cancer. This figure provides a comprehensive illustration of the regulatory loop between long non-coding RNAs (lncRNAs) and autophagy in gastric cancer (GC). Key mechanisms include signaling pathways (e.g., phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin), the regulation of protein stability and activity, and the reciprocal influence of autophagy on lncRNAs. These interactions impact critical biological processes in GC, such as proliferation, metastasis, chemoresistance, and tumor microenvironment regulation. These findings underscore the central role of the lncRNA-autophagy relationship in tumor progression and its potential as a therapeutic target. LncRNA: Long non-coding RNA; TME: Tumor microenvironment.