Luong TV, Cao MTT, Nguyen NVD, Dang HNN, Nguyen TT. Roles of autophagy and long non-coding RNAs in gastric cancer. World J Gastroenterol 2025; 31(11): 101124 [PMID: 40124267 DOI: 10.3748/wjg.v31.i11.101124]
Corresponding Author of This Article
Trung Tran Nguyen, PhD, Department of Biotechnology, NTT Hi-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh, Ho Chi Minh City 700000, Viet Nam. nguyen.trung@ntt.edu.vn
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Mar 21, 2025; 31(11): 101124 Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.101124
Roles of autophagy and long non-coding RNAs in gastric cancer
Thang Viet Luong, Mai Thi Thu Cao, Nam Van Duc Nguyen, Hai Nguyen Ngoc Dang, Trung Tran Nguyen
Thang Viet Luong, Nam Van Duc Nguyen, Department of Internal Medicine, University of Medicine and Pharmacy, Hue University, Hue 530000, Viet Nam
Mai Thi Thu Cao, Department of Biochemistry, University of Medicine and Pharmacy, Hue University, Hue 530000, Viet Nam
Hai Nguyen Ngoc Dang, Faculty of Medicine, Duy Tan University, Da Nang 550000, Viet Nam
Trung Tran Nguyen, Department of Biotechnology, NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Viet Nam
Co-first authors: Thang Viet Luong and Mai Thi Thu Cao.
Co-corresponding authors: Hai Nguyen Ngoc Dang and Trung Tran Nguyen.
Author contributions: Luong TV and Cao MTT were responsible for conceptualizing the study and writing the original draft of the manuscript; Dang HNN and Nguyen TT are designated as co-corresponding authors owing to their specific contributions; Dang HNN coordinated cross-departmental collaboration, maintained communication with external partners, supervised manuscript revisions, and created the figures, these roles were crucial to the successful completion of the study and manuscript preparation; Nguyen TT oversaw data collection and managed statistical analyses, ensuring methodological rigor, and conceptualized the design of the figures for the article; all the authors contributed to the writing, reviewing, editing, and drafting of the manuscript and have read and approved the final version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Trung Tran Nguyen, PhD, Department of Biotechnology, NTT Hi-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh, Ho Chi Minh City 700000, Viet Nam. nguyen.trung@ntt.edu.vn
Received: September 5, 2024 Revised: January 24, 2025 Accepted: February 17, 2025 Published online: March 21, 2025 Processing time: 189 Days and 1.4 Hours
Abstract
Gastric cancer (GC) is one of the most aggressive malignancies worldwide and is characterized by its poor prognosis and resistance to conventional therapies. Autophagy and long non-coding RNAs (lncRNAs) play critical yet complex roles in GC, functioning as both tumor suppressors and promoters depending on the disease stage and context. Autophagy influences cellular homeostasis and metabolism, whereas lncRNAs regulate gene expression through epigenetic modifications, RNA sponging, and protein interactions. Notably, the interplay between lncRNAs and autophagy modulates tumor progression, metastasis, chemoresistance, and the tumor microenvironment. This study explored the intricate relationship between lncRNAs and autophagy in GC, highlighting their roles in pathogenesis and treatment resistance. By addressing current knowledge gaps and proposing innovative therapeutic strategies, we have emphasized the potential of targeting this dynamic interplay for improved diagnostic and therapeutic outcomes.
Core Tip: Autophagy and long non-coding RNAs play pivotal roles in the progression of gastric cancer (GC), driving key processes such as tumor growth, metastasis, chemoresistance, and immune evasion. While each functions distinctly, their intricate interplay amplifies their impact, reshaping the gastric tumor microenvironment and accelerating disease progression. Understanding these mechanisms and their connections not only deepens our knowledge of GC pathogenesis but also unlocks new opportunities for innovative, targeted therapeutic strategies to combat this challenging disease.
