Metformin and pancreatic neuroendocrine tumors: A systematic review and meta-analysis

doi:10.3748/wjg.v30.i7.759

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 21, 2024; 30(7): 759-769
Published online Feb 21, 2024. doi: 10.3748/wjg.v30.i7.759

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Figure 1 PRISMA 2020 flow diagram. Selection of studies to review the diagnostic and prognostic value of type 2 diabetes mellitus and metformin for predicting the insurgence and post-treatment outcome of pancreatic neuroendocrine tumor.

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Figure 2 Association between type 2 diabetes mellitus and pancreatic neuroendocrine tumor. A: Forest plots of hazard ratios and 95%CIs for the association between type 2 diabetes mellitus (T2DM) and pancreatic neuroendocrine tumor (pNET) diagnosis; B: Forest plots of hazard ratios and 95%CIs for the association between T2DM and pNET tumor-free survival.

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Figure 3 Heterogenity of the studies exploring the association between type 2 diabetes mellitus and pancreatic neuroendocrine tumor. A and B: Galbraith plot (A) and Funnel plot (B) reporting the heterogeneity of the studies exploring the association between type 2 diabetes mellitus (T2DM) and pancreatic neuroendocrine tumor (pNET) diagnosis; C and D: Galbraith plot (C) and Funnel plot (D) reporting the heterogeneity of the studies exploring the association between T2DM and pNET tumor-free survival.

Citation: Cigrovski Berkovic M, Coppola A, Sesa V, Mrzljak A, Lai Q. Metformin and pancreatic neuroendocrine tumors: A systematic review and meta-analysis. World J Gastroenterol 2024; 30(7): 759-769
URL: https://www.wjgnet.com/1007-9327/full/v30/i7/759.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i7.759