Sirtuin 1 in regulating the p53/glutathione peroxidase 4/gasdermin D axis in acute liver failure

Figure 1 The activation of sirtuin 1 suppresses ferroptosis and pyroptosis in acute liver failure by inhibiting p53, glutathione peroxidase 4, and gasdermin D. The silent information regulator sirtuin 1 blocks p53 deacetylation and inhibits the glutathione peroxidase 4 (GPX4)/gasdermin D (GSDMD) signaling pathway, which in turn reduces hepatic iron overload and the inflammatory response. Ferroptosis and pyroptosis in acute liver failure are reduced by blocking the p53/GPX4/GSDMD signaling pathway. SIRT1: Silent information regulator sirtuin 1; SLC7A11: Solute carrier family 7a member 11; SLC3A2: Solute carrier family 3a member 2; GSH: Glutathione; GPX4: Glutathione peroxidase 4; GSDMD: Gasdermin D; IL1β: Interleukin-1 beta; ROS: Reactive oxygen species.