Sirtuin 1 in regulating the p53/glutathione peroxidase 4/gasdermin D axis in acute liver failure

doi:10.3748/wjg.v30.i34.3850

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Sep 14, 2024 (publication date) through Nov 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 14, 2024; 30(34): 3850-3855
Published online Sep 14, 2024. doi: 10.3748/wjg.v30.i34.3850

Sirtuin 1 in regulating the p53/glutathione peroxidase 4/gasdermin D axis in acute liver failure

Swati Katoch, Vikram Patial

Swati Katoch, Vikram Patial, Division of Dietetics and Nutrition Technology, Institute of Himalayan Bioresource Technology, Palampur 176061, Himachal Pradesh, India

Swati Katoch, Vikram Patial, Academy of Scientific and Innovative Research, Ghaziabad 201002, Uttar Pradesh, India

Author contributions: Katoch S collected the literature and wrote the manuscript; Patial V contributed to designing, manuscript writing and editing; Both authors have read and approved the final manuscript.

Supported by CSIR, India, No. MLP0204.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/

Corresponding author: Vikram Patial, PhD, Principal Scientist, Associate Professor, Division of Dietetics and Nutrition Technology, Institute of Himalayan Bioresource Technology, Post Box No. 6, Palampur 176061, Himachal Pradesh, India. vikrampatial@ihbt.res.in

Received: March 15, 2024
Revised: August 14, 2024
Accepted: August 21, 2024
Published online: September 14, 2024
Processing time: 178 Days and 20.1 Hours

Core Tip

Core Tip: Ferroptosis and pyroptosis are crucial modes of hepatic cell death in acute liver failure (ALF), and their close association leads to the sudden progression of liver failure. Silent information regulator sirtuin 1 inhibits p53 activity by deacetylation, thereby promoting cell survival. Inhibition of p53 activity affects downstream regulators like Glutathione peroxidase 4 (GPX4) and Gasdermin D (GSDMD). The overexpression of GPX4 and reduced levels of GSDMD protect the cell from pyroptosis and ferroptosis, indicating the close link between these mechanisms in ALF.