Association of tumor budding with clinicopathological features and prognostic value in stage III-IV colorectal cancer

Figure 1 Study design and flow diagram. CRC: Colorectal cancer.

Figure 2 Spearman correlation analysis was used to evaluate the consistency between tumor budding categories evaluated by two pathologists. R = 0.865, P < 0.001.

Figure 3 Univariable analysis of progression-free survival in colorectal cancer patients. AJCC: American Joint Committee on Cancer; HR: Hazard ratio.

Figure 4 Univariable analysis of overall survival in colorectal cancer patients. AJCC: American Joint Committee on Cancer; HR: Hazard ratio.

Figure 5 Multivariable Cox hazards model analysis on progression-free survival in colorectal cancer patients. AJCC: American Joint Committee on Cancer; HR: Hazard ratio.

Figure 6 Multivariable Cox hazards model analysis on overall survival in colorectal cancer patients. AJCC: American Joint Committee on Cancer; HR: Hazard ratio.

Figure 7 Kaplan–Meier survival analysis of survival in patients with Stage III-IV colorectal cancer according to grade of tumor budding. A: Overall survival in patients with Bd 1 and Bd 2-3; B: Progression-free survival in patients with Bd 1 and Bd 2-3.

Figure 8 Kaplan–Meier survival analysis of survival in patients with Stage III-IV colorectal cancer according to grade of tumor budding. A: Overall survival in the vascular invasion group; B: Progression-free survival in the vascular invasion group.

Figure 9 Kaplan–Meier survival analysis of survival in patients with Stage III-IV colorectal cancer according to grade of tumor budding. A: Overall survival in the perineural invasion group; B: Progression-free survival in the perineural invasion group.

Figure 10  Relationship between grade of tumor budding and tumor infiltrating lymphocytes. A: Bd 1 and Bd 2-3 with stromal tumor-infiltrating lymphocytes (TILs); B: Bd 1 and Bd 2-3 with TILs at the invasive margin.