Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2024; 30(2): 158-169
Published online Jan 14, 2024. doi: 10.3748/wjg.v30.i2.158
Association of tumor budding with clinicopathological features and prognostic value in stage III-IV colorectal cancer
Yue-Hao Luo, Zhe-Cheng Yan, Jia-Ying Liu, Xin-Yi Li, Ming Yang, Jun Fan, Bo Huang, Cheng-Gong Ma, Xiao-Na Chang, Xiu Nie
Yue-Hao Luo, Zhe-Cheng Yan, Jia-Ying Liu, Xin-Yi Li, Ming Yang, Jun Fan, Bo Huang, Cheng-Gong Ma, Xiao-Na Chang, Xiu Nie, Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Co-first authors: Yue-Hao Luo and Zhe-Cheng Yan.
Co-corresponding authors: Xiao-Na Chang and Xiu Nie.
Author contributions: Luo YH and Yan ZC contributed equally to this work; Luo YH, Yan ZC, Liu JY, Li XY, Yang M, and Fan J designed the research study; Luo YH, Huang B, and Ma CG performed the research; Luo YH, Chang XN, and Niu X analyzed the data and wrote the manuscript; All authors have read and approve the final manuscript.
Supported by National Key R&D Program of China, No. 2022YFF1203300.
Institutional review board statement: This study was approved by the review committee of the affiliated institution of Tongji Medical College of Huazhong University of Science and Technology (2018-S377).
Informed consent statement: Consent was obtained from all patients participating in the study.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiu Nie, MD, Professor, Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. niexiuyishi@126.com
Received: October 25, 2023
Peer-review started: October 25, 2023
First decision: November 12, 2023
Revised: November 23, 2023
Accepted: December 14, 2023
Article in press: December 14, 2023
Published online: January 14, 2024
Processing time: 78 Days and 15.4 Hours
Core Tip

Core Tip: This study included 547 colorectal cancer (CRC) patients. Tumor budding (TB) was evaluated independently by two pathologists and re-evaluated by a third pathologist when the results were inconsistent, ensuring a high level of reliability. The 2016 International Tumor Budding Consensus Conference recommendations were followed to evaluate TB in patients with stage III-IV CRC, thereby investigating its impact on patient prognosis. TB has predictive prognostic value for progression-free survival and overall survival in patients with stage III-IV CRC. It is recommended to complete the TB report of stage III-IV CRC cases in the standardized pathological report to further refine risk stratification.