Regional variation in routes to diagnosis of cholangiocarcinoma in England from 2006 to 2017

Figure 1 Flow diagram of eligible patients. iCCA: Intrahepatic cholangiocarcinoma; eCCA: Extrahepatic cholangiocarcinoma; CCA: Cholangiocarcinoma; ICD: International Classification of Disease.

Figure 2 Age at diagnosis for cholangiocarcinoma cohort diagnosed in England 2006-2017.

Figure 3 Routes to diagnosis of cholangiocarcinoma patients in England, 2006-2017. GP: General practitioner.

Figure 4 Routes to diagnosis according to Cancer Alliance of residence at diagnosis. GP: General practitioner.

Figure 5 Proportion of people diagnosed via a Two Week Wait referral in each Cancer Alliance: Results from linear probability model. A: Unadjusted estimates. Inner dashed line = 2 SD difference from average. Outer dashed line = 3 SD difference from average; B: Adjusted estimates. Inner dashed line = 2 SD difference from average. Outer dashed line = 3 SD difference from average. Adjustment for: age, gender, income deprivation quintile, Charlson comorbidity index, underlying liver disease, diagnosis year, tumour morphology and sub-type.

Figure 6 Proportion of people diagnosed via an emergency presentation in each Cancer Alliance: Results from linear probability models. A: Unadjusted estimates. Inner dashed line = 2 SD difference from average. Outer dashed line = 3 SD difference from average; B: Adjusted estimates. Inner dashed line = 2 SD difference from average. Outer dashed line = 3 SD difference from average. Adjustment for: Age, gender, income deprivation quintile, Charlson comorbidity index, underlying liver disease, diagnosis year, tumour morphology and sub-type.