Atherogenic index of plasma combined with waist circumference and body mass index to predict metabolic-associated fatty liver disease

Figure 1 Flow chart of the study subjects. MAFLD: Metabolic-associated fatty liver disease; MRI: Magnetic resonance imaging.

Figure 2 Receiver operating characteristic curves of atherogenic index of plasma in predicting metabolic-associated fatty liver disease in different subgroups. A: Comparison between the young (age < 40 years) and middle-age and elderly (age ≥ 40 years) subjects (P = 0.0102); B: Comparison between male and female subjects (P = 0.0639); C: Comparison between nonobese and obese subjects (P < 0.0001). AIP: Atherogenic index of plasma; AUC: Area under the receiver operating characteristic curve.

Figure 3 Calibration line and receiver operating characteristic curves of the A-W-B model. A: Calibration line of the prediction model combining atherogenic index of plasma, waist circumference, and body mass index (A-W-B) model (Hosmer-Lemeshow test: χ² = 8.5901, P = 0.3780); B: Receiver operating characteristic curve of the A-W-B model in the training set (area under the receiver operating characteristic curve [AUC] = 0.833); C: Receiver operating characteristic curve of the A-W-B model in the validation set (AUC = 0.862).

Figure 4 Receiver operating characteristic curves of the A-W-B model to predict metabolic-associated fatty liver disease in different subgroups. A: Comparison between young (age < 40 years) and middle-age and elderly (age ≥ 40 years) subjects (P = 0.0138); B: Comparison between male and female subjects (P = 0.0395); C: Comparison between nonobese and obese subjects (P = 0.0001); AUC: Area under the receiver operating characteristic curve; A-W-B: Prediction model combining atherogenic index of plasma, waist circumference, and body mass index.

Figure 5 Receiver operating characteristic curves of atherogenic index of plasma, waist circumference, body mass index, and A-W-B model to predict metabolic-associated fatty liver disease in different subgroups. A-E: The area under the receiver operating characteristic curve (AUC) of the prediction model combining atherogenic index of plasma, waist circumference (WC), and body mass index (BMI) (A-W-B) model was significantly higher than that of A-W-B in male, female, young, middle-aged and elderly, and nonobese subjects (all P < 0.01); F: The AUC of the A-W-B model was only better than atherogenic index of plasma (AIP) in obese subjects (P = 0.0465).

Figure 6 Correlation between A-W-B levels with liver proton density fat fraction and the severity of metabolic-associated fatty liver disease. A: The prediction model combining atherogenic index of plasma, waist circumference, and body mass index (A-W-B) level was strongly and positively associated with liver proton density fat fraction (PDFF) (r = 0.630, P < 0.001); B: Compared with the control group, ^bP < 0.001; compared with the mild group, ^aP < 0.01. MAFLD: Metabolic-associated fatty liver disease.