Effects of Granule Dendrobii on chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats

Figure 1 Changes in body weight of chronic atrophic gastritis rats during the 8-wk treatment period. Data were evaluated for statistical significance by one-way ANOVA, least significant difference test and Dunnett T3 test, and are presented as follows: ^aP < 0.05 and ^bP < 0.01 vs chronic atrophic gastritis with no-treatment group. GD High: Chronic atrophic gastritis rats treated with a high dosage of Granule Dendrobii; GD Medium: Chronic atrophic gastritis rats treated with a medium dosage of Granule Dendrobii; GD Low: Chronic atrophic gastritis rats treated with a low dosage of Granule Dendrobii; YWS: Chronic atrophic gastritis rats treated with Yangweishu; CAG: Chronic atrophic gastritis.

Figure 2 Pathological changes of gastric mucosa after treatment. A: Improved histopathology of gastric mucosa; B: Reduced inflammation of gastric mucosa; C and D: Treatment with Granule Dendrobii improved the thickness and gland number of gastric mucosa in rats with chronic atrophic gastritis; E and F: Treatment with Granule Dendrobii increased the number of chief cells and parietal cells in gastric mucosa in rats with chronic atrophic gastritis; G: Treatment with Granule Dendrobii improved intestinal metaplasia of gastric mucosa in rats with chronic atrophic gastritis. Data were evaluated for statistical significance by one-way ANOVA, least significant difference test and Dunnett T3 test, and are represented as follows: ^aP < 0.05 and ^bP < 0.01 vs chronic atrophic gastritis with no-treatment group. GD High: Chronic atrophic gastritis rats treated with a high dosage of Granule Dendrobii; GD Medium: Chronic atrophic gastritis rats treated with a medium dosage of Granule Dendrobii; GD Low: Chronic atrophic gastritis rats treated with a low dosage of Granule Dendrobii; YWS: Chronic atrophic gastritis rats treated with Yangweishu; CAG: Chronic atrophic gastritis.

Figure 3 Treatment with Granule Dendrobii decreased the expression of PCNA in gastric mucosa of chronic atrophic gastritis rats. A summary of the expression of PCNA and B-cell lymphoma-2 in gastric mucosa is indicated in Table 1. GD high: Chronic atrophic gastritis rats treated with a high dosage of Granule Dendrobii; CAG: Chronic atrophic gastritis.

Figure 4 Treatment with Granule Dendrobii improved hemoglobin and erythrocyte count in chronic atrophic gastritis rats. A: Hemoglobin count; B. Erythrocyte count. Data were evaluated for statistical significance by one-way ANOVA, least significant difference test and Dunnett T3 test, and are presented as follows: ^aP < 0.05 and ^bP < 0.01 vs chronic atrophic gastritis with no-treatment group. GD high: Chronic atrophic gastritis rats treated with a high dosage of Granule Dendrobii; GD medium: Chronic atrophic gastritis rats treated with a medium dosage of Granule Dendrobii; GD low: Chronic atrophic gastritis rats treated with a low dosage of Granule Dendrobii; YWS: Chronic atrophic gastritis rats treated with Yangweishu; CAG: Chronic atrophic gastritis.