Basic Study
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World J Gastroenterol. Aug 28, 2022; 28(32): 4668-4680
Published online Aug 28, 2022. doi: 10.3748/wjg.v28.i32.4668
Effects of Granule Dendrobii on chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats
Yue Wu, Yu Li, Xiao-Ming Jin, Guan-Hai Dai, Xuan Chen, Ye-Ling Tong, Ze-Ming Ren, Yu Chen, Xiao-Min Xue, Ren-Zhao Wu
Yue Wu, First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310052, Zhejiang Province, China
Yue Wu, Yu Li, Guan-Hai Dai, Xuan Chen, Ye-Ling Tong, Ze-Ming Ren, Xiao-Min Xue, Ren-Zhao Wu, Institute of Basic Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang Province, China
Yu Li, College of Basic Medicine, Zhejiang Chinese Medical University, Hangzhou 310052, Zhejiang Province, China
Xiao-Ming Jin, Stark Neuroscience Research Institute & Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Yu Chen, Department of Experimental Animals, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang Province, China
Author contributions: Wu RZ, Wu Y, Dai GH and Ren ZM designed the research; Wu Y, Li Y, Chen Y and Xue XM performed the research and acquired the data; Dai GH, Jin XM, Chen X and Tong YL analyzed and interpreted the data; Wu Y, Wu RZ and Jin XM wrote the manuscript; Wu Y and Jin XM extensively revised the manuscript for clarity and grammar; all authors have read and approve the final manuscript.
Supported by the Science and Technology Department of Zhejiang Province, No. LGF19H280008; and the Provincial Natural Science Foundation of Zhejiang Province, No. LY15H280011.
Institutional review board statement: The Institutional Review Board approval is not applicable in this study because it did not involve human beings.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by Zhejiang Academy of Traditional Chinese Medicine Research Ethics Committee.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data generated or analyzed during this study are included in this paper, and further inquiries can be directed to the corresponding author (E-mail: wufeng03@126.com).
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ren-Zhao Wu, MD, Chief Physician, Professor, Institute of Basic Medicine, Zhejiang Academy of Traditional Chinese Medicine, No. 132 Tianmushan Road, Xihu District, Hangzhou 310007, Zhejiang Province, China. wufeng03@126.com
Received: March 13, 2022
Peer-review started: March 13, 2022
First decision: June 11, 2022
Revised: June 23, 2022
Accepted: August 5, 2022
Article in press: August 5, 2022
Published online: August 28, 2022
Processing time: 165 Days and 19.4 Hours
Core Tip

Core Tip: Symptomatic treatment is mainly adopted for chronic atrophic gastritis (CAG) in modern medicine, and no drugs are available to promote gastric acid secretion and alleviate gastric gland atrophy. Our study shows that treatment with Granule Dendrobii (GD) for 8 wk was effective in reducing weight loss, gastric mucosal inflammation, atrophy and intestinal metaplasia, and loss of hemoglobin and erythrocytes in a rat model of CAG induced by N-methyl-N'-nitro-N-nitrosoguanidine. GD also alleviated the overexpression of PCNA and B-cell lymphoma-2 in CAG rats. These results provide new evidence on the use of GD not only for improving clinical symptoms but also for normalizing the abnormal histological changes of CAG.