Thrombocytopenia in chronic liver disease: Physiopathology and new therapeutic strategies before invasive procedures

Figure 1 Pathophysiology of thrombocytopenia. TPO: Thrombopoietin.

Figure 2 Pathophysiology of coagulopathy. ATIII: Antithrombin III; FVIII: Coagulation factor VIII; ADAMTS13: A disintegrin-like and metalloprotease with thrombospondin type 1 motif 13.

Figure 3 Overview of primary endpoints of phase 3 studies (ADAPT-1, ADAPT-2, L-PLUS 1, and L-PLUS 2). ^aP ≤ 0.0001.

Figure 4 Operative flow chart for management of thrombocytopenia in chronic liver disease. TPO-R: Thrombopoietin receptor; PLTs: Platelets; CID: Disseminated intravascular coagulation.