Novel index for the prediction of significant liver fibrosis and cirrhosis in chronic hepatitis B patients in China

Figure 1 Selection principles of study population. HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma.

Figure 2 Box plots of [alkaline phosphatase (U/L) + gamma-glutamyl transpeptidase (U/L)]/platelet (10⁹/L) (A), alkaline phosphatase + gamma-glutamyl transpeptidase (B), platelet (C), gamma-glutamyl transpeptidase to platelet ratio (D), aspartate aminotransferase-to-platelet ratio index (E), and age × aspartate transaminase/platelet × alanine aminotransferase (F) according to the METAVIR fibrosis stage in the training cohort. AGPR: [Alkaline phosphatase (U/L) + gamma-glutamyl transpeptidase (U/L)]/platelet (10⁹/L); ALP + γ-GT: Alkaline phosphatase + gamma-glutamyl transpeptidase; PLT: Platelet; GPR: Gamma-glutamyl transpeptidase to platelet ratio; APRI: Aspartate aminotransferase-to-platelet ratio index; FIB-4: Age × aspartate transaminase/platelet × alanine aminotransferase.

Figure 3 The receiver operating characteristic analysis of [alkaline phosphatase (U/L) + gamma-glutamyl transpeptidase (U/L)]/platelet (10⁹/L), amma-glutamyl transpeptidase to platelet ratio, aspartate aminotransferase-to-platelet ratio index and age × aspartate transaminase/platelet × alanine aminotransferase in the training (A) and validation cohorts (B). AGPR: [Alkaline phosphatase (U/L) + gamma-glutamyl transpeptidase (U/L)]/platelet (10⁹/L); GPR: Gamma-glutamyl transpeptidase to platelet ratio; APRI: Aspartate aminotransferase-to-platelet ratio index; FIB-4: Age × aspartate transaminase/platelet × alanine aminotransferase; AUC: Area under the curve.