Retrospective Study
Copyright ©The Author(s) 2022.
World J Gastroenterol. Jul 21, 2022; 28(27): 3488-3502
Published online Jul 21, 2022. doi: 10.3748/wjg.v28.i27.3488
Figure 1
Figure 1  Flow chart of the study.
Figure 2
Figure 2 Examples of different contrast-enhanced ultrasound Liver Imaging Reporting and Data System classes. A: Contrast-enhanced ultrasound (CEUS) LR-M. Notice rim arterial phase hyperenhancement and early washout, before 60 s; B: CEUS LR-5. Notice homogeneous arterial phase hyperenhancement, isoenhancement in portal phase, and mild washout in the late phase; C: CEUS LR-4. Notice homogeneous arterial phase hyperenhancement and isoenhancement in both portal and late phases; D: CEUS LR-3 iso-iso. Notice isoenhancement in all phases; E: CEUS LR-3 hypo-hypo. Notice hypoenhancement in all phases. The arrows show the target lesion.
Figure 3
Figure 3  Absolute frequency (n) of malignancies and benign lesions in LR-3 nodules and LR-3 subgroups with different contrast-enhanced ultrasound patterns.
Figure 4
Figure 4 Bangdiwala’s agreement charts of the Contrast-enhanced ultrasound Liver Imaging Reporting and Data System class assignments between different raters. In the case of perfect agreement, the k rectangles are represented by perfect squares and the shaded squares determined by the diagonal cell entries are exactly equal to the rectangles; lesser agreement is visualized by comparing the area of the blackened squares to the area of the rectangles. A: Agreement chart between the two internal raters (1 and 2), with the exclusion of LR-1 and LR-2 classes due to their rarity (n = 505); B-D: Agreement charts among the three raters from different centres (2, 3, and 4) for the subgroup of 50 nodules. We list the agreement charts between raters 2 and 3 (B), between raters 2 and 4 (C), and between raters 3 and 4 (D).

  • Citation: Vidili G, Arru M, Solinas G, Calvisi DF, Meloni P, Sauchella A, Turilli D, Fabio C, Cossu A, Madeddu G, Babudieri S, Zocco MA, Iannetti G, Di Lembo E, Delitala AP, Manetti R. Contrast-enhanced ultrasound Liver Imaging Reporting and Data System: Lights and shadows in hepatocellular carcinoma and cholangiocellular carcinoma diagnosis. World J Gastroenterol 2022; 28(27): 3488-3502
  • URL: https://www.wjgnet.com/1007-9327/full/v28/i27/3488.htm
  • DOI: https://dx.doi.org/10.3748/wjg.v28.i27.3488