Emerging role of colorectal mucus in gastroenterology diagnostics

Figure 1 Box and whisker plot and individual result distributions and receiver operating characteristic curve for the combined CALEDN test at stage 1 of the study. In the panel within the inflammatory bowel disease group, blue and red circles correspond to Crohn’s disease and ulcerative colitis cases, respectively. AUC: Area under the curve; IBS: Irritable bowel syndrome; CD: Crohn’s disease; UC: Ulcerative colitis. Citation: Loktionov A, Chhaya V, Bandaletova T, Poullis A. Inflammatory bowel disease detection and monitoring by measuring biomarkers in non-invasively collected colorectal mucus. J Gastroenterol Hepatol 2017; 32: 992-1002. Copyright© The Authors 2017. Published by John Wiley and Sons. A: Box and whisker plot; B: Receiver operating characteristic curve.

Figure 2 Receiver operating characteristic curves for ‘screening’ (blue) and ‘triage’ (red) settings for haemoglobin, C-reactive protein, tissue inhibitor of metalloproteinase 1, M2-pyruvate kinase, matrix metalloproteinase 9, peptidyl arginine deiminase-4, epidermal growth factor receptor, calprotectin and eosinophil-derived neurotoxin. A: Haemoglobin; B: CRP; C: TIMP1; D: M2-PK; E: MMP9; F: PADI4; G: EGFR; H: calprotectin; I: EDN. Citation: Loktionov A, Soubieres A, Bandaletova T, Francis N, Allison J, Sturt J, Mathur J, Poullis A. Biomarker measurement in non-invasively sampled colorectal mucus as a novel approach to colorectal cancer detection: screening and triage implications. Br J Cancer 2020; 123: 252-260. Copyright© The Authors 2020. Published by John Wiley and Sons.