Multiparameter magnetic resonance imaging of liver fibrosis in a bile duct ligation mouse model

Figure 1 Schematic diagram of bile duct ligation. A: Anatomy of the liver, bile duct, portal vein, and hepatic artery in mice; B: Exposure of the bile duct.

Figure 2 Magnetic resonance imaging findings and quantitative analysis. A: Box diagram of bile duct volume, ALT and AST in sham and BDL subgroups; B: Maximum cross-section of the bile duct or gallbladder on MRCP, T1-weighted, and T2-weighted images in sham and BDL subgroups. BDL: Bile duct ligation; MRCP: Magnetic resonance cholangiopancreatography; ALT: Alanine aminotransferase; AST: Aspartate transaminase. ^aP < 0.01 for comparison between and sham and liver fibrosis subgroups.

Figure 3 Functional parameter changes of magnetic resonance imaging and quantitative analysis. A: Maximum cross-section of liver parenchyma on T2 mapping, pre-, and post-enhanced T1 mapping in sham and BDL subgroups; B: Box diagram of T2 value, T1 value, and ΔT1 value in sham and BDL subgroups. BDL: Bile duct ligation. ^aP < 0.01 for comparison between and sham and liver fibrosis subgroups.

Figure 4 Masson's trichrome stain of the intrahepatic bile duct and hepatic parenchyma in sham and bile duct ligation subgroups (light microscopy, 400×). BDL: Bile duct ligation.

Figure 5 Spearman correlation coefficients between magnetic resonance imaging parameters with hepatic fibrosis rate. ALT: Alanine aminotransferase; AST: Aspartate transaminase.