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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2021; 27(47): 8156-8165
Published online Dec 21, 2021. doi: 10.3748/wjg.v27.i47.8156
Published online Dec 21, 2021. doi: 10.3748/wjg.v27.i47.8156
Multiparameter magnetic resonance imaging of liver fibrosis in a bile duct ligation mouse model
Jia-Yi Liu, Zhu-Yuan Ding, Zi-Yi Zhou, Sheng-Zhen Dai, Jie Zhang, Ye-Yu Cai, Quan-Liang Shang, Yong-Heng Luo, En-Hua Xiao, Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Hao Li, Department of Emergency Medicine, First People's Hospital of Changde City, Changde 415000, Hunan Province, China
Qiu Du, Department of Urology, Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University, Changsha 410005, Hunan Province, China
Author contributions: Liu JY, Luo YH and Xiao EH designed and coordinated the study; Liu JY, Ding ZY, Dai SZ performed the experiments, Li H, Du Q, Cai YY and Shang QL acquired and analyzed data; Shang QL interpreted the data; Liu JY and Luo YH wrote the manuscript; Luo YH and Xiao EH jointly supervised this work; all authors approved the final version of the article.
Supported by the Natural Science Foundation of Hunan Province , No. 2019JJ40444 (to Xiao EH) and 2021JJ30945 (to Luo YH) .
Institutional review board statement: The protocol of our study was approved by the Animal Care and Use Committee of the Second Xiangya Hospital of Central South University (Approval No. 2020495).
Conflict-of-interest statement: None of the authors have identified a conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Heng Luo, PhD, Attending Doctor, Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Renming Middle Road, Changsha 410011, Hunan Province, China. luoyongheng@csu.edu.cn
Received: April 18, 2021
Peer-review started: April 18, 2021
First decision: June 13, 2021
Revised: June 15, 2021
Accepted: September 19, 2021
Article in press: September 19, 2021
Published online: December 21, 2021
Peer-review started: April 18, 2021
First decision: June 13, 2021
Revised: June 15, 2021
Accepted: September 19, 2021
Article in press: September 19, 2021
Published online: December 21, 2021
Core Tip
Core tip: Magnetic resonance imaging (MRI) is promising for the noninvasive assessment of liver fibrosis, but the utility of multiparameter MRI in the bile duct ligation (BDL) mouse model has not been assessed. We established an experimental BDL mouse model that mimicked various aspects of cholestatic fibrosis and evaluated the potential of multiparameter MRI for the assessment of cholestatic fibrosis. We found that the BDL mouse model induced a complex cascade of changes that were observed clearly on MRI. The T2 and ΔT1 values were well correlated with the hepatic fibrosis rate and may allow for the detection of cholestatic fibrosis.