Breakthroughs and challenges in the management of pediatric viral hepatitis

doi:10.3748/wjg.v27.i20.2474

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May 28, 2021 (publication date) through Apr 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2021; 27(20): 2474-2494
Published online May 28, 2021. doi: 10.3748/wjg.v27.i20.2474

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Figure 1 Novel investigational approaches to chronic hepatitis. cccDNA: Covalently closed circular DNA; DNA-: Negative-sense DNA filament synthesis; DNA+: Positive-sense DNA filament synthesis; EGFR: Epidermal growth factor receptor; NTCP: Sodium taurocholate cotransporting polypeptide; HBcAg: Hepatitis B core antigen; HBeAg: Hepatitis B e antigen; HBsAg: Hepatitis B surface antigen; NAPs: Nucleic acid polymers; pgRNA: Pregenomic RNA; preC RNA: Pre-core RNA; PRR: Pattern recognition receptor; rcDNA: Relaxed circular DNA; SVP: Small viral particle; TLR: Toll-like receptor.

Citation: Nicastro E, Norsa L, Di Giorgio A, Indolfi G, D'Antiga L. Breakthroughs and challenges in the management of pediatric viral hepatitis. World J Gastroenterol 2021; 27(20): 2474-2494
URL: https://www.wjgnet.com/1007-9327/full/v27/i20/2474.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i20.2474