Serum N-glycan markers for diagnosing liver fibrosis induced by hepatitis B virus

Figure 1 A typical desialylated N-glycan profile from the total serum protein is shown in panels. The structures of the N-glycan peaks are shown below the panels. Peak 1 indicates an agalacto core-α-1,6-fucosylated biantennary glycan (NGA2F), peak 2 indicates an agalacto core-α-1,6-fucosylated bisecting biantennary glycan (NGA2FB), peaks 3 and 4 indicate a single agalacto core-α-1,6-fucosylated biantennary glycan (NG1A2F), peak 5 indicates a bigalacto biantennary glycan (NA2), peak 6 indicates a bigalacto core-α-1,6-fucosylated biantennary glycan (NA2F), peak 7 indicates a bigalacto core-α-1,6-fucosylated bisecting biantennary glycan (NA2FB), peak 8 indicates a triantennary glycan (NA3), peak 9 indicates a branching α-1,3-fucosylated triantennary glycan (NA3Fb).

Figure 2 Receiver operating characteristic curve. A: Receiver operating characteristic (ROC) curve for the prediction of fibrosis F0-F1 from fibrosis F2-F4 in the modeling group. [area under ROC curves (AUROCs): Model A (0.890) > GlycoCirrhoTest (0.644) > GlycoFibroTest (0.538)]; B: ROC curve for the prediction of fibrosis F0-F2 from fibrosis F3-F4. [AUROCs: Model B (0.752) > GlycoCirrhoTest (0.618) > GlycoFibroTest (0.524)]; C: ROC curve for the prediction of fibrosis F0-F3 from fibrosis F4. [AUROCs: Model C (0.747) > GlycoCirrhoTest (0.607) > GlycoFibroTest (0.571)].