Review
Copyright ©The Author(s) 2019.
World J Gastroenterol. Sep 7, 2019; 25(33): 4835-4849
Published online Sep 7, 2019. doi: 10.3748/wjg.v25.i33.4835
Figure 1
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Figure 1 Transforming growth factor-β mediated crosstalk network in liver fibrosis. TGF-β is primarily signaled by intracellular Smads. TGF-β: Transforming growth factor-β; HSC: Hepatic stellate cell; NK: Natural killer.
Figure 2
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Figure 2 Toll-like receptor mediated crosstalk network in liver fibrosis. Toll-like receptor is a member of DAMPs that recognize pathogen-associated molecules and thereby transmit inflammatory signals that cause inflammatory responses. TLR: Toll-like receptor; MAPK: Mitogen-activated protein kinase; NF-кB: Nuclear factor-кB; HSC: Hepatic stellate cell; DC: Dendritic cells; NK: Natural killer.
Figure 3
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Figure 3 STAT3-mediated inflammatory mediator crosstalk network in liver fibrosis. EGFR: Epidermal growth factor receptor; HSC: Hepatic stellate cell; TGF-β: Transforming growth factor-β; MAPK: Mitogen-activated protein kinase; IL: Interleukin.
Figure 4
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Figure 4 Inflammatory mediator network between cytokines and signaling pathway in liver fibrosis. TGF-β: Transforming growth factor-β; IL: Interleukin.