Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2019; 25(33): 4835-4849
Published online Sep 7, 2019. doi: 10.3748/wjg.v25.i33.4835
Published online Sep 7, 2019. doi: 10.3748/wjg.v25.i33.4835
Crosstalk network among multiple inflammatory mediators in liver fibrosis
Han-Jing Zhangdi, Si-Biao Su, Fei Wang, Zi-Yu Liang, Yu-Dong Yan, Shan-Yu Qin, Hai-Xing Jiang, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Zhangdi HJ wrote the manuscript; Zhangdi HJ and Jiang HX designed the study; all other authors equally contributed to this paper with regard to manuscript drafting, critical revision, and editing.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hai-Xing Jiang, PhD, Director, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, No. 6, Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. ce28meseq@sina.com
Telephone: +86-13978867818 Fax: +86-771-78867818
Received: July 12, 2019
Peer-review started: July 12, 2019
First decision: July 22, 2019
Revised: July 24, 2019
Accepted: August 7, 2019
Article in press: August 7, 2019
Published online: September 7, 2019
Processing time: 60 Days and 20.3 Hours
Peer-review started: July 12, 2019
First decision: July 22, 2019
Revised: July 24, 2019
Accepted: August 7, 2019
Article in press: August 7, 2019
Published online: September 7, 2019
Processing time: 60 Days and 20.3 Hours
Core Tip
Core tip: Liver fibrosis is a chronic liver lesion with inflammation. Reciprocally, increased inflammatory response exacerbates the severity of liver disease. Clinical data reveal that an aberrant increase of inflammatory cytokines is highly correlated with poor outcome of patients with liver fibrosis. However, the mechanism underlying liver fibrosis is not completely understood. It is urgently needed to enrich the knowledge of liver fibrosis. This review focuses on the role of inflammation in liver fibrosis and discusses the crosstalk network involving immune cells, cytokines, and the related signaling pathways.