Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer

Figure 1 Schematic diagram of cell systemic evolution of ligands by exponential enrichment strategy. The target cells are used to screen and enrich the selection pools, and clonal sequencing is performed to obtain the required aptamers. SELEX: Systemic evolution of ligands by exponential enrichment.

Figure 2 Schematic diagram of aptamer targeting to liver cancer. The aptamers bind to the surface of the liver cancer cells with high specificity and high affinity after incubation with the liver cancer cells. After the aptamers are injected into the mouse model through the tail vein, they specifically bind to the liver cancer tissue site.