Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations

Figure 1 Comparison of Prostaglandin E-major urinary metabolites concentrations between chronic enteropathy associated with SLCO2A1 gene (n = 20) and Crohn’s disease (n = 98) groups. Prostaglandin E-major urinary metabolite concentrations in the chronic enteropathy associated with SLCO2A1 gene group were significantly higher than those in the Crohn’s disease group [median (interquartile range): 102.7 (62.0-155.0) µg/g × Cre vs 27.9 (19.6-40.0) µg/g × Cre, P < 0.0001]. Mann-Whitney U-test. CEAS: Chronic enteropathy associated with SLCO2A1 gene; CD: Crohn’s disease; PEG-MUM: Prostaglandin E-major urinary metabolite.

Figure 2 Receiver operating characteristic curve of Prostaglandin E-major urinary metabolites concentrations for differentiation between chronic enteropathy associated with SLCO2A1 gene and Crohn’s disease. The area under the receiver operating characteristic curve was 0.90 (95% confidence interval, 0.82-0.95). The optimal cut-off value was 48.9 µg/g × Cre.