Differentiation of intrahepatic cholangiocarcinoma from hepatocellular carcinoma in high-risk patients: A predictive model using contrast-enhanced ultrasound

Figure 1 Flowchart of the intrahepatic cholangiocarcinoma and hepatocellular carcinoma patient selection process. CEUS: Contrast-enhanced ultrasound; HCC: Hepatocellular carcinoma; ICC: Intrahepatic cholangiocarcinoma.

Figure 2 Contrast-enhanced ultrasound images demonstrate the enhancement features of intrahepatic cholangiocarcinoma and hepatocellular carcinoma.

Figure 3 Contrast-enhanced ultrasound score nomogram and liver imaging reporting and data system nomogram for intrahepatic cholangiocarcinoma prediction. A: Constructed contrast-enhanced ultrasound score nomogram and liver imaging reporting and data system nomogram; B: ROC curves for the two nomograms in the training and validation set; C: ROC curves for the two nomograms in ≤ 5.0 cm and ≤ 3.0 cm subgroup analysis. CEUS: Contrast-enhanced ultrasound; LI-RADS: Liver imaging reporting and data system; ICC: Intrahepatic cholangiocarcinoma; HCC: Hepatocellular carcinoma.

Figure 4 Calibration plots of the contrast-enhanced ultrasound score nomogram and liver imaging reporting and data system nomogram applied in the training (A), validation cohort (B), as well as ≤ 5. 0 cm (C) and ≤ 3.0 cm subgroup (D). CEUS: Contrast-enhanced ultrasound; LI-RADS: Liver imaging reporting and data system.

Figure 5 Decision curve analysis of the contrast-enhanced ultrasound score nomogram and liver imaging reporting and data system nomogram in the training (A) and validation cohort (B). CEUS: Contrast-enhanced ultrasound; LI-RADS: Liver imaging reporting and data system.