Retrospective Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2018; 24(33): 3786-3798
Published online Sep 7, 2018. doi: 10.3748/wjg.v24.i33.3786
Differentiation of intrahepatic cholangiocarcinoma from hepatocellular carcinoma in high-risk patients: A predictive model using contrast-enhanced ultrasound
Li-Da Chen, Si-Min Ruan, Jin-Yu Liang, Zheng Yang, Shun-Li Shen, Yang Huang, Wei Li, Zhu Wang, Xiao-Yan Xie, Ming-De Lu, Ming Kuang, Wei Wang
Li-Da Chen, Si-Min Ruan, Jin-Yu Liang, Yang Huang, Wei Li, Zhu Wang, Xiao-Yan Xie, Ming-De Lu, Ming Kuang, Wei Wang, Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Zheng Yang, Department of Pathology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Shun-Li Shen, Ming-De Lu, Ming Kuang, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Author contributions: Chen LD, Ruan SM, Wang W, Xie XY, Lu MD, Kuang M designed the research; Chen LD, Ruan SM, Wang W, Liang JY, Huang Y performed the research; Chen LD and Ruan SM contributed equally to the design and preparation of this study and should be considered co-first authors; Li W, Wang Z contributed new reagents or analytical tools; Yang Z, Shen SL analyzed data; Chen LD, Ruan SM wrote the paper.
Supported by the National Nature Science Foundation of China, No. 81701719; the Guangdong Science and Technology Foundation, No. 2017A020215195; and the Guangdong Medical Scientific Research Foundation, No. A2016254.
Institutional review board statement: This study was approved by the Institutional Review Board of the First Affiliated Hospital of Sun Yat-Sen University.
Informed consent statement: Informed consent was obtained from each patient.
Conflict-of-interest statement: The authors have declared no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wei Wang, MD, PhD, Associate Professor, Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan Road 2, Guangzhou 510080, Guangdong Province, China. wangw73@mail.sysu.edu.cn
Telephone: +86-20-87765183 Fax: +86-20-87765183
Received: May 7, 2018
Peer-review started: May 7, 2018
First decision: May 16, 2018
Revised: June 30, 2018
Accepted: July 16, 2018
Article in press: July 16, 2018
Published online: September 7, 2018
Processing time: 122 Days and 22.5 Hours
Core Tip

Core tip: A contrast-enhanced ultrasound (CEUS) score for predicting intrahepatic cholangiocarcinoma (ICC) consisting of more detailed CEUS features was constructed. The diagnostic performance of the CEUS score for differentiation between ICC and hepatocellular carcinoma were improved compared to the LR-M of the Liver Imaging Reporting and Data System (LI-RADS). A CEUS score nomogram, which added the clinical risk factors, was superior to the LI-RADS nomogram.