Fecal microbial dysbiosis in Chinese patients with inflammatory bowel disease

Figure 1 Alpha diversity indices boxplot, including community richness (observed species, chao, ace) and diversity (Shannon, Simpson) varied among each group. A: Observed species; B: Chao; C: Ace; D: Shannon; E: Simpson. ^aP < 0.05 vs control. CD: Crohn’s disease; UC: Ulcerative colitis.

Figure 2 Principal component analysis based on the overall structure of the fecal microbiota in the entire study population. Each data point represents an individual sample. A: Disease phenotype group; B: Stages of disease group. CD: Crohn’s disease; CD.A: Active CD; CD.I: Inactive CD; UC: Ulcerative colitis; UC.A: Active UC.

Figure 3 Taxonomic composition distribution in samples of phylum level. A: Individually; B: Integrally. CD: Crohn’s disease; CD.A: Active CD; CD.I: Inactive CD; UC: Ulcerative colitis; UC.A: Active UC.

Figure 4 A: The taxonomic composition distribution in samples of genus level; B: Genera shown represent the 10 most abundant genera of CD, UC and control. ^aP < 0.05 vs control, ^cP < 0.05 vs CD. CD: Crohn’s disease; UC: Ulcerative colitis.

Figure 5 Correlation of the relative abundance of Bacteroidetes and Proteobacteria with Crohn’s disease activity index scores (A). Bacteroidetes (r = -0.538, P = 0.039); Proteobacteria (r = 0.250, P = 0.369); B: Microbial composition of Bacteroidetes in patients with inactive/mild/moderate CD and in control; C: Microbial composition of Proteobacteria in patients with inactive/mild/moderate CD and in controls. ^aP < 0.05 vs control; ^cP < 0.05 vs CD.mild; ^eP < 0.05 vs CD.moderate. CDAI: CD activity index; CD.I: Inactive CD; CD.mild: Mild CD; CD.moderate: Moderate CD.