Metabolomic profiling for identification of metabolites and relevant pathways for taurine in hepatic stellate cells

Figure 1 Principal component analysis plots of biological metabolites for taurine in hepatic stellate cells in electrosprayionization⁺ mode (A) and in electrosprayionization^- mode (B). HSCs: Hepatic stellate cells; ESI: Electrosprayionization.

Figure 2 Partial least square discriminant analysis and validation of biological metabolites for taurine in hepatic stellate cells in electrosprayionization⁺ mode and in electrosprayionization^- mode. A: Partial least square discriminant analysis (PLS-DA) plots of biological metabolites for taurine in hepatic stellate cells (HSCs) in ESI⁺ mode; B: PLS-DA plots of biological metabolites for taurine in HSCs in ESI^- mode; C: Validation of biological metabolites for taurine in HSCs in ESI⁺ mode; D: Validation of biological metabolites for taurine in HSCs in ESI^- mode. ESI: Electrosprayionization; HSCs: Hepatic stellate cells.

Figure 3 Potential pathways for taurine in hepatic stellate cells identified by using MetPA pathway analysis. ^aSphingolipid metabolism pathway; ^bGlutathione metabolism pathway; ^cThiamine metabolism pathway.

Figure 4 Sphingolipid metabolism pathway.

Figure 5 Glutathione metabolism pathway.

Figure 6 Thiamine metabolism pathway.