Substantial hepatic necrosis is prognostic in fulminant liver failure

Figure 1 Mass and submassive liver necrosis. A: Low power magnification showing complete hepatocellular necrosis in a core biopsy (× 40); B: Medium power magnification showing a liver biopsy with perivenular predominant hepatocellular necrosis and intermixed viable hepatocytes located around the portal tract (× 40); C: High magnification of image A showing hepatocellular necrosis and profound inflammatory infiltrate in which the architecture of hepatocyte is preserved (× 200); D: High magnification of image B reveals the collapse of parenchyma that is replaced by necroinflammatory infiltrate in comparison to the adjacent viable hepatocytes in the right upper corner (× 200).