Helicobacter pylori BabA in adaptation for gastric colonization

Figure 1 In BabA generalists the serine (S) at position 198 makes the DL1 domain to be accessible for the glycan found on blood group A, B as well as O antigen whereas in BabA specialists the replacement of S to leucine (L) makes DL1 to be inaccessible for binding with larger glycans present on blood group A and B antigen.

Figure 2 Cytosine-thiamidine-dinucleotide repeats and slipped strand mis-pairing. Both replicating and template strands are prone to undergo for slippage mis-pairing. Slippage occurring in replicating strand during first generation of replication causes insertion of one CT-dinucleotide in replicating strand whereas the template strand contains original number of CT-dinucleotide. If slippage occurs in template strand during first generation replication, one CT-dinucleotide is deleted in replicating strand to make base paring. During second generation of DNA replication, out of two progeny generating from slippage in replicating strand, one progeny contains DNA with one CT-dinucleotide more than the mother strain while the other progeny contains same number of CT-dinucleotide as mother strain. During second generation of DNA replication, out of two progeny generating from slippage in template strand, one progeny contains DNA with one CT-dinucleotide less than the mother strain while other progeny contains DNA with same number of CT-dinucleotide as do mother strain. CT: Cytosine-thiamidine.