hsa-miR-29c and hsa-miR-135b differential expression as potential biomarker of gastric carcinogenesis

Figure 1 Expression values of hsa-miR-29c in samples of normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinal-type gastric adenocarcinoma, respectively (values in log scale). P values were obtained by ANOVA test (adjusted by using Bonferroni’s correction).

Figure 2 Expression values of hsa-miR-135b in samples of normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinal-type gastric adenocarcinoma, respectively (values in log scale). P values were obtained by ANOVA test (adjusted by using Bonferroni’s correction).

Figure 3 Comparison of the expression values of hsa-miR-135b between samples of Helicobacter pylori-positive non-atrophic chronic gastritis and Helicobacter pylori-negative non-atrophic chronic gastritis (P = 0. 011). H. pylori: Helicobacter pylori.

Figure 4 Receiver operating characteristic curve analysis of hsa-miR-29c (A-E) and hsa-miR-135b (F-J) expression. Gastric lesions: Non-atrophic chronic gastritis and intestinal metaplasia; Others: Non-atrophic chronic gastritis, intestinal metaplasia and intestinal-type gastric adenocarcinoma; AUC: Area under the curve.

Figure 5 Categorical principal components analysis of hsa-miR-29c expression in two dimensions. Vectors making 180-degree indicate they are closely and negatively related. Vectors making a 90-degree angle indicate they are not related.

Figure 6 Categorical principal components analysis of hsa-miR-135b expression in three dimensions in two different angles (A and B). Vectors making 180-degree indicate they are closely and negatively related. Vectors making a 90-degree angle indicate they are not related. H. pylori: Helicobacter pylori.