Tropomyosin-related kinase B/brain derived-neurotrophic factor signaling pathway as a potential therapeutic target for colorectal cancer

Figure 1 TrkB-mediated signaling pathways and possible therapeutic targets in cancer. Schematic representation of TrkB receptor, its main downstream signaling pathways, and possible therapeutic targets. Shc: Src homology 2 domain containing transforming protein; Grb2: Growth factor receptor-bound protein 2; Gab1: Grb2 associated binding protein 1; PI3K: Phosphatidylinositol 3-kinase; PDK1: Phosphoinositide-dependent protein kinase 1; mTOR: Mammalian target of rapamycin; mTORC1: mTOR complex 1; SOS: Son of sevenless; MEK: Mitogen-activated protein kinase (MAPK)/ERK kinase; ERK: Extracellular signal-regulated kinase; PLC: Phospholipase C; PKC: Protein kinase C.