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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2016; 22(2): 490-500
Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.490
Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.490
Tropomyosin-related kinase B/brain derived-neurotrophic factor signaling pathway as a potential therapeutic target for colorectal cancer
Hussein Akil, Aurélie Perraud, Marie-Odile Jauberteau, Muriel Mathonnet, Laboratoire Homéostasie Cellulaire et Pathologies (LHCP-EA3842), Faculté de Médecine et de Pharmacie, Fédération de Recherche GEIST, 87025 Limoges, France
Aurélie Perraud, Muriel Mathonnet, Service de Chirurgie Digestive, Générale et Endocrinienne, CHU de Limoges, 87042 Limoges, France
Marie-Odile Jauberteau, Service d’Immunologie, CHU de Limoges, 87042 Limoges, France
Author contributions: Akil H wrote and designed the paper; Jauberteau MO and Mathonnet M contributed equally to this work; and Akil H, Perraud A, Jauberteau MO and Mathonnet M contributed to conception, critical revision and final approval of the manuscript.
Supported by Conseil Régional du Limousin and the CORC Comité Orientation Recherche Cancer.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hussein Akil, PhD, Laboratoire Homéostasie Cellulaire et Pathologies (LHCP-EA3842), Faculté de Médecine et de Pharmacie, Fédération de Recherche GEIST, Université de Limoges, 2 rue du Dr Marcland, 87025 Limoges, France. hussein.akil@outlook.fr
Telephone: +33-555-435868 Fax: +33-555-435916
Received: April 25, 2015
Peer-review started: April 27, 2015
First decision: September 11, 2015
Revised: September 25, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: January 14, 2016
Peer-review started: April 27, 2015
First decision: September 11, 2015
Revised: September 25, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: January 14, 2016
Core Tip
Core tip: Recently, the tropomyosin-related kinase B (TrkB)/brain derived-neurotrophic factor (BDNF) signaling pathway has emerged as a key player in the pathogenesis and prognosis of several non-neural cancers. Indeed, the TrkB tyrosine kinase receptor has been recently found to play an important role in the biological and clinical behavior of colorectal cancer (CRC). Here, we review the implications of TrkB and its ligand BDNF in CRC. Additionally, we discuss possible therapeutic strategies targeting this pathway.