Precore/basal core promoter mutants quantification throughout phases of hepatitis B virus infection by Simpleprobe

Figure 1 Precore, basal core promoter mutation distribution throughout phases of hepatitis B virus infection. Log₁₀ precore, log₁₀ basal core promoter value (A, B), precore%, basal core promoter (%) (C, D) distribution through the phases of hepatitis B virus infection; disease progression can be estimated by the combination of log₁₀ precore, log₁₀ basal core promoter and precore%, basal core promoter (%) (E). PC: Precore; BCP: Basal core promoter; IT: Immune tolerance; IC: Immune clearance; LR: Low-replicative; ENH: HBeAg-negative hepatitis; HBeAg: Hepatitis B early antigen; PC%: PC mutant quantity per total viral load; BCP%: BCP mutant quantity per total viral load.

Figure 2 Precore, basal core promoter mutation distribution by patient age subgroup and hepatitis B early antigen status. Age subgroup vs PC mutation percentage (PC%) (A), and BCP mutation percentage (BCP%) (B); Age subgroup vs log₁₀ PC (C) and log₁₀ BCP (D); HBeAg status vs PC% (E) and BCP% (F); HBeAg status vs log₁₀ PC (G) and log₁₀ BCP (H). Short horizontal lines flanking the means indicate SE. PC: Precore; BCP: Basal core promoter; PC%: PC mutant quantity per total viral load; BCP%: BCP mutant quantity per total viral load; HBV: Hepatitis B virus; ALT: Alanine aminotransferase; HBeAg: Hepatitis B early antigen.

Figure 3 Correlation between hepatitis B early antigen titer and total log₁₀ hepatitis B virus DNA (A); log₁₀ precore, log₁₀ basal core promoter value (B); and precore%, basal core promoter (%) (C).

Figure 4 Differential subgroup distributions of precore%, basal core promoter (%) and hepatitis B early antigen titers. PC: Precore; BCP: Basal core promoter; PC%: PC mutant quantity per total viral load; BCP%: BCP mutant quantity per total viral load.