Epstein Barr virus-positive mucocutaneous ulcer of the colon associated Hodgkin lymphoma in Crohn’s disease

Figure 1 Hematoxylin and eosin staining of the colectomy specimen (magnification × 40). Scattered Hodgkin/Reed-Sternberg-like cells are present in a polymorphous background of lymphocytes, histiocytes and eosinophils. Muscularis propria is seen in the upper left of the field.

Figure 2 Epstein Barr virus-encoded small RNAs in situ hybridisation of the colectomy specimen (magnification × 40). The Hodgkin/Reed-Sternberg-like cells show strong nuclear staining, indicating Epstein-Barr virus positivity.

Figure 3 Persistence of ulceration in the sigmoid colon 18 mo post methotrexate and infliximab cessation.