Systematic review: Laparoscopic fundoplication for gastroesophageal reflux disease in partial responders to proton pump inhibitors

Figure 1 Search strategy.

Figure 2 Proportion of patients reporting heartburn, regurgitation and dysphagia symptoms during preoperative proton pump inhibitor treatment and at follow-up after laparoscopic fundoplication. Superscript numbers indicate individual studies. A: Heartburn; B: Regurgitation; C: Dysphagia.

Figure 3 Effects of laparoscopic fundoplication on esophageal acid exposure (assessed by ambulatory 24-h H measurement) and resting lower esophageal sphincter pressure (assessed by esophageal manometry). Data are shown for before and after laparoscopic fundoplication (LF) (follow-up period: 0.25-1 year). A: Esophageal acid exposure [baseline taken during proton pump inhibitors (PPIs) treatment]; B: Lower esophageal sphincter pressure (LESP) (baseline taken during PPI abstinence).

Figure 4 Proportion of patients using acid-suppressive medication (A) and requiring surgical reintervention (B) after laparoscopic fundoplication.