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©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jan 21, 2014; 20(3): 804-813
Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.804
Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.804
Systematic review: Laparoscopic fundoplication for gastroesophageal reflux disease in partial responders to proton pump inhibitors
Lars Lundell, Department of Surgery, CLINTEC, Karolinska Institutet, S141 86 Stockholm, Sweden
Martin Bell, Research Evaluation Unit, Oxford PharmaGenesis™ Ltd., Oxford, OX13 5QJ, United Kingdom
Magnus Ruth, Shire-Movetis NV, B-2300 Turnhout, Belgium
Author contributions: All authors contributed substantially to the conception and design of the study, analysis and interpretation of data, drafting and revision of the manuscript, and approved the final version of the manuscript.
Supported by AstraZeneca R and D, Mölndal, Sweden
Correspondence to: Lars Lundell, MD, Professor of Medicine, Department of Surgery, CLINTEC, Karolinska Institutet, S141 86 Stockholm, Sweden. lars.lundell@karolinska.se
Telephone: +46-8-58580549 Fax: +46-8-58586366
Received: July 5, 2013
Revised: October 21, 2013
Accepted: November 13, 2013
Published online: January 21, 2014
Processing time: 228 Days and 21.2 Hours
Revised: October 21, 2013
Accepted: November 13, 2013
Published online: January 21, 2014
Processing time: 228 Days and 21.2 Hours
Core Tip
Core tip: There are no high-level evidence to support the use of laparoscopic fundoplication (LF) in partial responders to proton pump inhibitor (PPI) therapy. The evidence that does exist suggests LF improves symptom control in these patients, but symptoms recur over time. There are limited data to suggest that LF is not as efficacious in partial responders as in those with an adequate response to PPI therapy.