DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer

doi:10.3748/wjg.v20.i25.8201

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2014; 20(25): 8201-8208
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8201

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Figure 1 Immunohistochemical staining of DNA methyltransferases in gastric cancer. DNA methyltransferase (DNMT) 1 (A), DNMT3a (C), and DNMT3b (E) positive immunostaining in gastric carcinoma cells. Negative expression of DNMT1 (B), DNMT3a (D), and DNMT3b (F) in gastric carcinoma tissues. Original magnification, × 200.

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Figure 2 Kaplan-Meier curves of the survival for gastric cancer patients with DNA methyltransferase expression (Log-rank test). A, C: No significant correlations between DNA methyltransferase 1 (DNMT1) and DNMTb expression and the overall survival time (P = 0.289, P = 0.347); B: Positive DNMT3a expression was significantly associated with poor survival in gastric cancer (P = 0.032).

Citation: Cao XY, Ma HX, Shang YH, Jin MS, Kong F, Jia ZF, Cao DH, Wang YP, Suo J, Jiang J. DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer. World J Gastroenterol 2014; 20(25): 8201-8208
URL: https://www.wjgnet.com/1007-9327/full/v20/i25/8201.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i25.8201